While it is well known that hyperthyroidism leads to weight loss, and hypothyroidism is associated with weight gain, there has been an increasing focus on the relationship between thyroid function and body weight in recent years. A moderate elevation of TSH concentrations, which is associated with triiodothyronine (T3) values in or slightly above the upper normal range, is frequently found in obese humans. These thyroid hormone alterations in obesity seem rather a consequence than a cause of obesity since weight loss leads to a normalization of elevated thyroid hormone levels. The underlying pathways are not fully understood. White adipose tissue, the largest energy store in the body, actively produces various hormones, cytokines, and chemokines, which together exert important roles in homeostasis and also in thyroid hormone regulation. The adipokine leptin seems to be the most promising link between body weight and TSH levels since leptin stimulates the hypothalamic–pituitary–thyroid axis.
More at link: http://www.endocrine-abstracts.org/e...a0029S59.1.htm
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