Marshall: So these have been termed: the tried and true vaccine mechanism, when it comes to COVID. Specifically compared to the mRNA vaccines, what vaccines currently use this or employ this technology?
Griffin: I think that is interesting. We definitely have a lot of people and they say, "yeah, all these mRNAs, when's the normal coming? I want the normal vaccine." I think there's a couple of things when people say they want the normal vaccine.
One is they, I think they're thinking of something like the J&J. I just want to get one shot and then be done.
Marshall: One and done. Exactly.
Griffin: One and done exactly. I'm sure that will be part of their marketing campaign. They also want a vaccine that: I want a vaccine that like hundreds of thousands of people have gotten this technology. I don't want to be one of the first people.
And that's where the adenoviral vaccines come in. We've been working with these really since the 1970s. We've been studying, working with these. So not just two decades, but I guess we're going to say 50 years, five decades.
This was the technology that was used when they had issues with Ebola, right, in West Africa. They were very able to quickly get a couple of these up and running. Two Ebola vaccines were actually engineered using the viral vector technology, and were used in a couple hundred thousand people in the outbreaks in West Africa and the Democratic Republic of Congo.
So yeah, in many ways this is technology that hundreds of thousands of people have used. We have a side effect profile. We have safety profile data. And now with AstraZeneca and J&J we have a couple of COVID vaccines with really good, good data as well as really impressive safety profiles.
Marshall: Now, this is interesting, Dr. Griffin, because you mentioned that the research goes back five decades, but you only really mentioned the Ebola vaccine. Is that the only vaccine that currently exists because that's only a couple of years old?
Griffin: Yeah. The challenge with vaccine technology has often been the market for our newer ideas. Right. You know, we do the flu vaccine, a number of the childhood vaccines. But we really have a price point for vaccines being: "Oh, it's only going to cost a few dollars."
I don't think we've appreciated until this current pandemic, how valuable it can be to spending money on vaccines and getting new technologies out there. We've been working with these viral vectors for decades now. But it wasn't until we had issues like Zika, RSV, malaria. And then as I mentioned, the Ebola outbreaks, where we really took these viral vectors and really got them out there to hundreds of thousands of people.
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https://www.medpagetoday.com/podcasts/trackthevax/91323
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