In the initial impression from consecutive 200 patients, the average of myocardial SUVmax was 6.2 in 139 vaccinated patients and 4.8 in 61 non-vaccinated patients in 8 weeks, therefore effect size was estimated at 0.36 and allocation ratio was estimated at 2.3.
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The study included 303 nonvaccinated patients (mean age, 52.9 years; 157 females) and 700 vaccinated patients (mean age, 56.8 years; 344 females). Vaccinated patients had overall higher myocardial FDG uptake compared to nonvaccinated patients (median SUVmax, 4.8 vs median SUVmax, 3.3 ; P < .0001). Myocardial SUVmax was higher in vaccinated patients regardless of sex (median range, 4.7-4.9 ) or patient age (median range, 4.7-5.6) compared to corresponding nonvaccinated groups (sex median range, 3.2-3.9; age median range, 3.3-3.3; P range, <.001-.015). Furthermore, increased myocardial FDG uptake was observed in patients imaged 1-30, 31-60, 61-120, and 121-180 days after their second vaccination (median SUVmax range, 4.6-5.1) and increased ipsilateral axillary uptake was observed in patients imaged 1-30, 31-60, 61-120 days after their second vaccination (median SUVmax range, 1.5-2.0) compared to the nonvaccinated patients (P range, <.001-<.001).
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