The absolute counts of total white blood cells (WBCs) (5.29 × 109/L) and lymphocytes (1.51 × 109/L) of non-severe COVID-19 patients in the first week of illness were significantly lower than those of the healthy donors in group one (6.01 × 109/L, P = 0.007 and 1.85 × 109/L, P = 0.001, respectively).
(...)
The absolute counts of lymphocytes in healthy donors in group two (1.74 × 109/L) were significantly higher than those of patients with severe COVID-19 (0.81 × 109/L, P = 0.001), severe influenza A (0.87 × 109/L, P < 0.0001). Patients with severe COVID-19 and severe influenza A had a significantly lower number of total T cells (P = 0.001 and P < 0.0001, respectively), CD4+ T cells (P = 0.001 and P < 0.0001, respectively), and CD8+ T cells (P = 0.002 and P < 0.0001, respectively) than healthy controls in group two.
(...)
Collectively, our study suggests the plausible role of lymphocyte subsets in disease progression, which in turn affects prognosis and recovery duration in patients with severe COVID-19 and influenza A.
Connect With Us