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Thread: Chloroquine: What Do We Know?

  1. #1

    Exclamation Chloroquine: What Do We Know?

    Even more promising news on this drug.


    Chloroquine: What Do We Know?

    https://thenationalpulse.com/news/ch...at-do-we-know/

    Raheem Kassam March 23, 2020

    As the numbers of infected and dead coronavirus patients continue to tick up, we’ve begun to hear of hydroxychloroquine, a well-known anti-viral drug used for years to treat malaria, Lyme disease, and rheumatoid arthritis (RA).

    Chloroquine is FDA-approved and has been for many years. It is available and inexpensive (as low as 3 cents per pill for hydroxychloroquine).

    There appears to be some evidence that this is effective in treating COVID-19. Three medical studies have confirmed that in using chloroquine to treat the virus, one hundred percent of patients treated have been cured, in as little as six days. No one has died.

    This could be the game-changer of game-changers.

    While chloroquine has not yet been FDA-approved to treat COVID-19, some doctors are already using it.

    Dr. William Grace, an oncologist at Lenox Hill Hospital in New York City, appeared on Fox News on Thursday night, telling host Laura Ingraham that doctors at his hospital had treated almost one hundred ‘very sick’ COVID-19 patients with hydroxychloroquine, a less toxic form of chloroquine, and Azithromycin.

    There have been no deaths among these patients.

    He says colleagues at other New York hospitals are also using it, and there have been no deaths at these facilities, either.

    Dr. Grace was careful to note they were only using it with patients who showed ‘major respiratory compromise’, that the real danger with the virus was having the patient’s lungs fill with fluid, something the drug tended to arrest. Ingraham noted that just because the drug had not yet been FDA-approved for use in treating COVID-19, it did not mean that doctors could not use it in clinical settings.

    As with all medications, chloroquine can have side effects.

    As recently as 2013, the FDA relabeled the warnings on chloroquine to include possible side effects such as dizziness, loss of balance, ringing in the ears, anxiety, depression, and hallucinations. But it’s important to note many patients do not experience these effects at all, and for those that do, these side effects are serious but do not lead to fatalities.

    At the same time, we’re also learning that malaria outbreaks in countries which regularly experience them might be a predicting factor in how many cases of COVID-19 break out in that country. In a strange inverse ratio, the more cases of malaria a country experiences regularly, the fewer cases of COVID-19 seem to be showing up in those countries.

    Is this just a coincidence, or is it an important consideration in potentially identifying, quantifying and/or treating this pandemic

    Consider what Dr. Roy Spencer, Principal Research Scientist at the University of Alabama in Huntsville since 2001, posted on his Facebook page on March 18th:

    Roy W. Spencer
    last Wednesday
    WOW.

    On the subject of using antimalarial drugs for COVID-19 treatment, I've compared COVID-19 cases versus malaria incidence by country....

    This is amazing. I downloaded all of the data for 234 countries, incidence of total COVID-19 cases (as of 3/17/2020) versus the incidence of malaria in those countries (various sources, kinda messy matching everything up in Excel).

    RESULTS, Multi-country average malaria cases per thousand, COVID-19 cases per million, in three classes of countries based on malaria incidence:

    Top 40 Malaria countries: 212 malaria = 0.2 COVID-19;
    Next 40 Malaria countries: 7.3 malaria = 10.1 COVID-19
    Remaining (81-234) countries: 0.00 malaria = 68.7 COVID-19

    Again, the units are Malaria cases per thousand "population at risk", and COVID-19 cases per million total population.

    In all my years of data analysis I have never seen such a stark and strong relationship: Countries with malaria basically have no COVID-19 cases (at least not yet).
    As investigators look further at this interesting relationship between malaria and COVID-19, it’s important to determine, if these numbers hold up with additional analysis, why this is so.

    And is it possible that since countries affected by malaria are already using chloroquine as an effective remedy, and since presumably at least part of their population in the recent past has used chloroquine as a treatment for malaria… could the chloroquine they had ingested previously be already, somehow, protecting them from developing COVID-19?

    Maybe the real correlation here is that countries using chloroquine regularly for another reason are already protecting their population (even if unknowingly) against another deadly virus. If so, chloroquine’s efficacy as a prophylactic may already be at least partially proven.
    Another mark of a tyrant is that he likes foreigners better than citizens, and lives with them and invites them to his table; for the one are enemies, but the Others enter into no rivalry with him. - Aristotle's Politics Book 5 Part 11



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  3. #2
    I hope they have enough production of that drug in the United States and don't have to get it from someplace else.

  4. #3
    Quote Originally Posted by Anti Federalist View Post
    could the chloroquine they had ingested previously be already, somehow, protecting them from developing COVID-19
    its should be noted here that chloroquine and hyroxychloroquine are in two entirely different categories with regard to duration in the body and dosing regimines.

    chloroquine taken previously is likely not protecting anyone; its dose response to viral infection requires a dose that is very near dangerous to have any effect. Thereafter its halflife in the body is about 48 hours.

    hydroxychloroquine has considerably wider gap between effective and lethal dose; though still tight relative to many other drugs. The halflife however is extremely long and it depends on the individual in question as to how fast it is metabolized. It can have an in vivo halflife of 20 to 60 days. This is part of the reason you should only take this under doctor's care. You don't just take it once a day... you take it... and before you take it again... you test to see how much remains in the system; an "assay test". If you stack doses on something that has month long halflife and small window of therapeutic range... you can quickly reach lethal dosing.

    but yes... hydroxychloroquine taken in the past month for malaria... could in theory have pronounced prophylactic effect
    Last edited by presence; 03-23-2020 at 03:56 PM.

    'We endorse the idea of voluntarism; self-responsibility: Family, friends, and churches to solve problems, rather than saying that some monolithic government is going to make you take care of yourself and be a better person. It's a preposterous notion: It never worked, it never will. The government can't make you a better person; it can't make you follow good habits.' - Ron Paul 1988

    Awareness is the Root of Liberation Revolution is Action upon Revelation

    'Resistance and Disobedience in Economic Activity is the Most Moral Human Action Possible' - SEK3

    Flectere si nequeo superos, Acheronta movebo.

    ...the familiar ritual of institutional self-absolution...
    ...for protecting them, by mock trial, from punishment...


  5. #4
    Quote Originally Posted by presence View Post
    its should be noted here that chloroquine and hyroxychloroquine are in two entirely different categories with regard to duration in the body and dosing regimines.

    chloroquine taken previously is likely not protecting anyone; its dose response to viral infection requires a dose that is very near dangerous to have any effect. Thereafter its halflife in the body is about 48 hours.

    hydroxychloroquine has considerably wider gap between effective and lethal dose; though still tight relative to many other drugs. The halflife however is extremely long and it depends on the individual in question as to how fast it is metabolized. It can have an in vivo halflife of 20 to 60 days. This is part of the reason you should only take this under doctor's care. You don't just take it once a day... you take it... and before you take it again... you test to see how much remains in the system; an "assay test". If you stack doses on something that has month long halflife and small window of therapeutic range... you can quickly reach lethal dosing.

    but yes... hydroxychloroquine taken in the past month for malaria... could in theory have pronounced prophylactic effect
    How do each metabolize?

    I'm assuming liver and fat cells if fatal dosages can build up.
    Another mark of a tyrant is that he likes foreigners better than citizens, and lives with them and invites them to his table; for the one are enemies, but the Others enter into no rivalry with him. - Aristotle's Politics Book 5 Part 11

  6. #5
    Quote Originally Posted by Anti Federalist View Post
    How do each metabolize?

    I'm assuming liver and fat cells if fatal dosages can build up.
    unfortunately you're getting beyond my level of understanding and I don't wish to mislead

    'We endorse the idea of voluntarism; self-responsibility: Family, friends, and churches to solve problems, rather than saying that some monolithic government is going to make you take care of yourself and be a better person. It's a preposterous notion: It never worked, it never will. The government can't make you a better person; it can't make you follow good habits.' - Ron Paul 1988

    Awareness is the Root of Liberation Revolution is Action upon Revelation

    'Resistance and Disobedience in Economic Activity is the Most Moral Human Action Possible' - SEK3

    Flectere si nequeo superos, Acheronta movebo.

    ...the familiar ritual of institutional self-absolution...
    ...for protecting them, by mock trial, from punishment...




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