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Thread: Study: Zika Virus Kills Brain Cancer Cells

  1. #1

    Default Study: Zika Virus Kills Brain Cancer Cells

    https://www.sciencedaily.com/release...0905093623.htm

    While Zika virus causes devastating damage to the brains of developing fetuses, it one day may be an effective treatment for glioblastoma, a deadly form of brain cancer. New research shows that the virus kills brain cancer stem cells, the kind of cancer cells most resistant to standard treatments.
    The findings suggest that the lethal power of the virus -- known for infecting and killing cells in the brains of fetuses, causing babies to be born with tiny, misshapen heads -- could be directed at malignant cells in the brain. Doing so potentially could improve people's chances against a brain cancer -- glioblastoma -- that is most often fatal within a year of diagnosis.

    "We showed that Zika virus can kill the kind of glioblastoma cells that tend to be resistant to current treatments and lead to death," said Michael S. Diamond, MD, PhD, the Herbert S. Gasser Professor of Medicine at Washington University School of Medicine and the study's co-senior author.

    The findings are published Sept. 5 in The Journal of Experimental Medicine.
    * Enforce Border Security – America should be guarding her own borders and enforcing her own laws instead of policing the world and implementing UN mandates.

    * No Amnesty - The Obama Administration’s endorsement of so-called “Comprehensive Immigration Reform,” granting amnesty to millions of illegal immigrants, will only encourage more law-breaking.

    * Abolish the Welfare State – Taxpayers cannot continue to pay the high costs to sustain this powerful incentive for illegal immigration. As Milton Friedman famously said, you can’t have open borders and a welfare state.

    * End Birthright Citizenship – As long as illegal immigrants know their children born here will be granted U.S. citizenship, we’ll never be able to control our immigration problem.




    Reprinted from http://www.ronpaul2012.com/the-issues/immigration/ [Nov. 29, 2011]



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  3. #2

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    Hmm...I guess that is good news for John McCain. But what about those mosquitoes?

    1947 ROCKEFELLER PATENT SHOWS ORIGINS OF ZIKA VIRUS: AND WHAT ABOUT THOSE GENETICALLY MODIFIED MOSQUITOES?



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  4. #3

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    Quote Originally Posted by donnay View Post
    Hmm...I guess that is good news for John McCain. But what about those mosquitoes?

    1947 ROCKEFELLER PATENT SHOWS ORIGINS OF ZIKA VIRUS: AND WHAT ABOUT THOSE GENETICALLY MODIFIED MOSQUITOES?



    http://www.collective-evolution.com/...ed-mosquitoes/
    That isn't a patent. It is a listing at a site which sells samples of things like viruses to researchers. The name is the person who provided them with that particular sample. The "VR- 84" is their file number. 1947 is when that sample was collected.

    Their website: https://www.atcc.org/

    Link to the actual Zika page: https://www.atcc.org/products/all/VR-84.aspx
    Last edited by Zippyjuan; 09-07-2017 at 03:57 PM.
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  5. #4

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    I’ve heard some bizarre stories on the Zika virus, that since it was discovered by the Rockefeller foundation in 1947, and then in 2015 suddenly started to misform babies’ heads (microcephaly)…
    I’ve also heard strange stories about cancer treatment, not in the least that cancer can be fought with vaccines: http://www.ronpaulforums.com/showthr...ancer-vaccines

    This is one of the worst written “scientific” reports I’ve ever read, it doesn’t even have a separate “conclusion” and “discussion”. Here it is for anybody that wants to read it – Zhe Zhu et al “Zika virus has oncolytic activity against glioblastoma stem cells”: http://jem.rupress.org/content/early...5/jem.20171093

    To test the effects of ZIKV on normal adult human neural cells, we inoculated nonmalignant neural tissues from adult epilepsy specimens (Fig. 3, T–V). ZIKV did not infect normal adult human brain tissues, including NeuN+ neurons (Fig. 3, W and Y) and GFAP+ glial cells (Fig. 3, X and Z), as limited viral replication was detected compared with glioblastomas (Fig. S2, N and O). In addition, compared with GSCs and DGCs, the human brain neural cell cultures that were derived from epilepsy patients (NM55 and NM177) or from differentiated human neural stem cells (Hu-DNCs) demonstrated limited ZIKV infection (Fig. S2, P–U).
    (…)
    We recapitulated relevant conditions for human brain tumor therapy using mice. As mice are not natural hosts for ZIKV, pathogenesis studies have used animals with acquired or genetic deficiencies of type I IFN signaling (Lazear et al., 2016). To overcome this limitation, we used a mouse-adapted ZIKV-Dakar that had gained virulence through passage in a Rag1−/− host (Govero et al., 2016; Sapparapu et al., 2016).
    (…)
    To. assess the oncolytic effects of ZIKV in vivo, we generated mouse gliomas from two different mouse cell lines (GL261 and CT-2A) grown in syngeneic hosts. Glioma cells were transduced with a luciferase reporter and permitted to form tumors, which were validated by bioluminescence imaging and histopathology (Fig. 4, C–E). Mice with tumors were randomized into two groups and treated 2 wk after implantation with either PBS control or mouse-adapted ZIKV-Dakar (103 focus-forming units [FFU]). Histological examination at 1 wk after tumor treatment demonstrated that the ZIKV-treated tumors were smaller in size compared with PBS-treated tumors (Fig. 4, F–I).

    Notably, ZIKV infection extended the life spans of tumor-bearing mice (Fig. 4 J). To test whether tumor-bearing mice could benefit from a higher dose of virus, we inoculated 105 FFU of the mouse-adapted ZIKV-Dakar at 1 wk after implantation with the GL261 model. The survival time of tumor-bearing mice was greater compared with that of the control or the 103-FFU dose (Fig. 4 K). To determine the specificity of cell targeting, we stained for ZIKV antigen and markers of stem cell proliferation and differentiation (Fig. 4, L–T). ZIKV infected ∼6% of glioma cells at the endpoint (Fig. 4 T), with the majority of these cells expressing the precursor marker SOX2 (Fig. 4, L, M, and T). In contrast, GFAP+ tumor cells were less infected (Fig. 4, N and O). Effects on proliferating cell populations were measured by Ki-67 staining and BrdU treatment and staining.
    The following pictures reportedly shows cancer cells on the left, and on the right after treatment with Zika, the cancer has disappeared.
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  6. #5

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    Quote Originally Posted by Firestarter View Post

    This is one of the worst written “scientific” reports I’ve ever read, it doesn’t even have a separate “conclusion” and “discussion”. ]
    I literally laughed out loud.
    * Enforce Border Security – America should be guarding her own borders and enforcing her own laws instead of policing the world and implementing UN mandates.

    * No Amnesty - The Obama Administration’s endorsement of so-called “Comprehensive Immigration Reform,” granting amnesty to millions of illegal immigrants, will only encourage more law-breaking.

    * Abolish the Welfare State – Taxpayers cannot continue to pay the high costs to sustain this powerful incentive for illegal immigration. As Milton Friedman famously said, you can’t have open borders and a welfare state.

    * End Birthright Citizenship – As long as illegal immigrants know their children born here will be granted U.S. citizenship, we’ll never be able to control our immigration problem.




    Reprinted from http://www.ronpaul2012.com/the-issues/immigration/ [Nov. 29, 2011]

  7. #6

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    Florida and Texas will 'stop mosquitoes spreading Zika and other viruses' by using military planes to spray chemicals
    http://www.dailymail.co.uk/news/arti...chemicals.html
    "Logic is an enemy and truth is a menace." ~ Rod Serling
    "Cops today are nothing but an armed tax collector" ~ Frank Serpico
    "To be normal, to drink Coca-Cola and eat Kentucky Fried Chicken is to be in a conspiracy against yourself."
    "People that don't want to make waves sit in stagnant waters."

  8. #7

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    Quote Originally Posted by Zippyjuan View Post
    That isn't a patent. It is a listing at a site which sells samples of things like viruses to researchers. The name is the person who provided them with that particular sample. The "VR- 84" is their file number. 1947 is when that sample was collected.

    Their website: https://www.atcc.org/

    Link to the actual Zika page: https://www.atcc.org/products/all/VR-84.aspx
    They trademarked a file number?
    The object of life is not to be on the side of the majority, but to escape finding one’s self in the ranks of the insane.” — Marcus Aurelius


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