Ibuprofen health warning: Cheap painkiller raises the risk of heart disease, stroke and high b

[donnay]

Ibuprofen health warning: Cheap painkiller raises the risk of heart disease, stroke and high blood pressure in arthritis sufferers

By Stephen Matthews For Mailonline
PUBLISHED: 04:36 EDT, 29 August 2017

Arthritis sufferers are at greater risk of heart disease and stroke if they take ibuprofen to dampen their pain, a study shows.

The common painkiller, available in corner shops, supermarkets and petrol stations, had a more profound effect on raising blood pressure than other similar medications.

The findings, made by Swiss researchers, adds to a growing body of evidence that suggests the cheap pills may have deadly consequences.

Scientists warned the results of the trial is worrying for the elderly, considering their higher rates of arthritis and hypertension.

Frank Ruschitzka, professor of cardiology and head of the department at University Heart Centre, Zurich, was behind the study of arthritis patients who often rely on ibuprofen.

A 'clear demonstration'

He said: 'The study clearly demonstrates that non-steroidal anti-inflammatory drugs (NSAIDs), particularly ibuprofen, may be not as safe as previously thought.

'Patients receiving ibuprofen had a 61 per cent higher incidence of hypertension compared to those receiving celecoxib.'


Read more: http://www.dailymail.co.uk/health/ar...#ixzz4rBqYu4KD
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[opal]

Well I went to *cringe* the daily mail and read more
what a load of nothing for information!

the daily mail author really is a hack... really needs more info to be considered more than click bait.. like where's the links to the abstract, results, funding sources? Did they basically take data and analyze it again, like the last cardio "bad news" study?

They're not doing actual studies.. they're analyzing sketchy data.

The last abstract I read on an ibuprofen "study".. somewhere in the Netherlands I think.. maybe Denmark went through hospital admissions for 3 months.. found the cardiac patients - then went and "asked" them if they had taken OTC ibuprofen in the 3 months prior to their cardiac event.
Not how long.. not how much.. just if they had taken ANY over a 3 month period. Just drug store motrin.. no clue to the manufacturer.. no info on what sort of crap is in the coatings of those OTC pills... not prescription strength.. not under a doctor's instruction or care and some how came up with conclusive results that ibuprofen causes and or contributes to cardiac "events"

There was no information on who paid for the study.

Motrin came out in the 70s and it works. Yes, there is a chance of ulcers/bleeding if not taken properly, with food. Most of my family has been taking it for decades for whatever ails us.. toothaches, back pains, knee injuries, arthritis, menstrual pain.. headaches and ya know what.. not one person in my family has had a heart attack. Two grandparents died before it was invented.. the other two lived into their 90s, one dying from complications after a fall.. brain bleed and the other was killed by chemo. Mom died of obamacare and dad has a stint from a blockage of some sort over a decade ago.. still takes ibuprophen. A couple of siblings.. cousins.. nieces and nephews.. my kid.. various aunts and uncles. no motrin complications - in over 40 years. I have one aunt that cannot take it.. it makes her retain water like a blimp.

My tin foil hat may be on too tight here .. ibuprofen didn't start getting a bad rep until people started using weed to replace opiates on a way bigger scale than big pharma expected. Ibuprofen is relatively cheap, doesn't require a prescription any more for the training size pills and is way cheaper than the prescription pain killers they're trying to sell. As always, follow the money for the truth

[Firestarter]

Here’s another article about this study: https://www.escardio.org/The-ESC/Pre...ovascular-risk

Ibuprofen is associated with increased blood pressure and hypertension compared to celecoxib in patients with osteoarthritis or rheumatoid arthritis and increased risk of cardiovascular disease, according to late-breaking results from the PRECISION-ABPM study presented today in a Hot Line LBCT Session at ESC Congress (1) and published in EHJ.

Here’s the scientific looking report, Ruschitzka et al “Differential blood pressure effects of ibuprofen, naproxen, and celecoxib in patients with arthritis …”: https://academic.oup.com/eurheartj/a...s-of-ibuprofen
See figure 3 from the study.




Here’s an earlier study that showed a 31% increase in cardiac arrest risk because of Ibuprofen.
K.B. Sondergaard et al – Non-steroidal anti-inflammatory drug use is associated with increased risk of out-of-hospital cardiac arrest: a nationwide case–time–control study (2016): https://academic.oup.com/ehjcvp/arti...ry-drug-use-is
The following figure from the report shows the increased risk of a heart attack caused by Ibuprofen and Diclofenac.

[angelatc]

Well I went to *cringe* the daily mail and read more
what a load of nothing for information!

the daily mail author really is a hack...

They call it "The Daily Fail" in some circles. But this was a double-blind study, so it's got some legitimacy.

I find it fascinating how selective some of us can be when deciding which government big pHARMa studies are legitimate and which ones are fabricated. It's almost like there's a confirmation bias in play.

[angelatc]

Here’s the scientific looking report]

LOL! Some people call it the actual study.

[donnay]

This Is Your Body on Ibuprofen



How NSAIDS — nonsteroidal anti-inflammatory drugs such as ibuprofen, naproxen, and aspirin — can cause more pain than they relieve.

Maggie Quale was used to pain. A professional ballerina in her late 20s, she made a practice of pushing her body up to — and often past — its limits. During the day, she strived to perform dazzling arabesques and grand jetés. At night, she fell asleep replaying the day’s exercises in her head. She knew she was obsessive about dance but felt it was the only way to be successful. And she didn’t want to let her mounting injuries get in the way.

“It was torture to be out of class or rehearsals for one to two days, let alone weeks or months,” says Quale, now a 37-year-old PR consultant and mother of three boys. “Your strength, physique, and technique start to go very quickly, so we would all rush back prematurely and end up dancing with unhealed injuries.”

To push herself past the pain, Quale took Advil. Lots of it.

“All dancers and athletes pop Advil like candy,” she says. “I think a lot of us are under the illusion that we have cast-iron stomachs and that it won’t ever hurt us.”

Then, during intense rehearsals for The Nutcracker, her stomach gave way. Her pain felt like intense hunger, a nonstop gnawing in her gut. After a couple of days, it changed to sharper pain — like the tip of a knife pressed into her sternum. A trip to the doctor confirmed what she feared: All that Advil had given her an ulcer.

Quale is hardly the first athlete to suffer an injury from nonsteroidal anti-inflammatory drugs, known as NSAIDs (pronounced “N-seds”). This group of medications includes ibuprofen (with such over-the-counter brands as Advil and Motrin), naproxen (Aleve), and aspirin. (For a list of other NSAIDs, see “Common NSAIDs” below.)

Former Seattle Seahawks football player Kenny Easley was famously diagnosed with severe kidney disease in 1988, the result of taking large amounts of ibuprofen after ankle surgery. Easley had swallowed the ibuprofen hoping to reduce the inflammation around his ankle and get back on the field; instead, the damage to his kidneys ended his career.

Even nonathletes unwittingly oversuse NSAIDs. Physicians annually write nearly 100 million prescriptions for the drugs in the United States, 20 million in England, and 10 million in Canada. In addition, people buy billions of nonprescription NSAIDs over the counter each year. Americans alone annually purchase 30 billion NSAID tablets, whether in two-pill foil pouches at the airport or in 1,000-count bottles at big-box stores.

Most consumers immediately discard the accompanying instructions that warn of the dangers of these medications without reading them. And even the most dire of those warnings — called “black box” warnings and ordered by the FDA for products that may cause serious adverse reactions — don’t present the full picture of the dangers NSAIDs pose, both immediately and over time.

“If you go someplace and say you have a headache, it seems as if everyone has some NSAIDs in their purse or backpack or drawer,” says Sunil Pai, MD, medical director of Sanjevani Integrative Medicine in Albuquerque. “But I’d say at least 95 percent of the population, as well as most doctors and pharmacists, don’t know that there is a black-box warning on all NSAIDs.”

That lack of knowledge can be deadly.

Every year, some 100,000 people are hospitalized in the United States with gastrointestinal bleeding from taking NSAIDs, and 16,500 of them die.

Even that statistic, as horrible as it is, doesn’t present the full picture.

NSAIDs can increase the risk for illness in many different parts of the body, and they can interfere with the body’s natural healing process. Overuse can trigger a spiral of inflammation that results in autoimmune disease.

And here’s the shocker: Some people who take NSAIDs over a long period of time may actually worsen the underlying condition that causes their pain and inflammation.

A Slippery Slope
NSAIDs made their debut back in the 19th century, when the active ingredient for aspirin was isolated from a family of shrubs that ancient Egyptians used for aches and pains. By 1969, demand for stronger painkillers produced another NSAIDs contender: ibuprofen, which was introduced as a treatment for rheumatoid arthritis. This was followed by naproxen in 1976.

Like acetaminophen (sold under brand names such as Tylenol and Anacin), NSAIDs reduce pain and fever. But unlike acetaminophen, NSAIDs also reduce inflammation. (For more, see “Taking Acetaminophen? Handle With Care,” below.)

NSAIDs battle inflammation by inhibiting the action of two enzymes: cyclooxygenase 1 and cyclooxygenase 2, referred to as COX 1 and COX 2. These enzymes create lipids called prostaglandins, which regulate gastrointestinal, renal, vascular, and other physiological functions. These same enzymes also create a cascade of pain, fever, and inflammation when there’s a problem with our bodies. That’s one of the concerns about taking these medications: They mask valuable signals that we have a problem and allow us to push past the pain over and over, sometimes causing greater injury.

Another concern arises from the fact that these prostaglandins have many other important jobs within the body, and NSAIDs can block them all. So when we treat our pain, fever, and inflammation, we also negatively affect other critically important functions throughout the body, with the resulting problems:

BLEEDING ULCERS.



Maggie Quale’s experience with ibuprofen is quite common — in fact, people who take NSAIDs are five times as likely to develop ulcers as people who do not. The problem is that the prostaglandins produced by the COX 1 enzyme also protect the mucosal stomach lining from the acids we produce to break down our foods, and when we take NSAIDs, these acids can pierce the lining and cause sores, or ulcers, that bleed. And because some NSAIDs also thin the blood, we can lose an alarming amount of blood through the lining.

LEAKY GUT SYNDROME.



Read more: https://experiencelife.com/article/t...-on-ibuprofen/