...
Various forms of kratom and teas made from the plant’s leaves are sold in cafes and on the internet. Their primary effect is to provide a short-lived peaceful and calm feeling that is described as pleasant. Consistent with this effect being opioid-like, anecdotal reports indicate that some users have used kratom to successfully recover from physical and psychological dependence on prescription opioids and heroin. Comments on my last report on kratom have also indicated the successful use of teas made from the plant in managing chronic pain without the side effects and addictive potential of prescription opioids like oxycodone, hydrocodone and morphine.
In the last two months, published research has pointed to why kratom might be a useful and safer alternative to prescription opioids. The main component of the herb, the alkaloid mitragynine, and its metabolite and oxidation product, 7-hydroxymitragynine, produce an effect on the mu subtype of opioid receptors away from many of the mechanisms that cause many opioid side effects. These alkaloids are now shown to be so-called G-protein biased ligands at the mu opioid receptor. This effect minimizes the engagement of an intracellular protein called beta-arrestin that among other effects, causes a reduction in opioid receptors on the surface of cells, leading to the tolerance and dose escalation commonly seen with prescription opioids.
The CDC has reported in July that kratom can be abused and that poison control centers have received over
660 calls between 2010 and 2015 regarding kratom intoxication. This report has been criticized as being relatively inconsequential given the small number of cases when compared with other legal and illegal intoxicants. In some cases listed as kratom intoxication, other illicit drugs were taken by the individuals.
....
Connect With Us