Peanut Allergy
During the late 1940’s and throughout the fifties, peanut oil in penicillin was not suspect. It was used not only in this wonder drug, but in streptomycin, broad-spectrum antibiotics, injected epinephrine for asthma, in anesthetics and vaccines. Unknown to consumers, peanut oil was a popular ingredient in vitamins, skin cream and even infant formulas!
Prior to 1941, the literature shows no report of peanut allergies in adults or children. A survey of people showed self-reported peanut allergies in .3% of those born 1944-47, .4% of those born 1948-57, and .6% between 1959-67. In 2008, over 1% of people born 1944-67, reported allergies to nuts, including peanuts.
Articles published in the late 1950’s and early 1960’s show a growing awareness of peanut allergy, but the first formal study of peanut allergy in children was not launched until 1973, and then on only 114 kids. Doctors watched the mysterious rise in peanut allergies, but few asked “why?” By the early 1990’s tens of thousands of peanut allergic kindergartners entered school, not only in the U.S., but in Canada, the United Kingdom and in Australia. This allergy accelleration was concurrent with an unprecedented push of political, social, legal and economic reforms to alter and accelerate the vaccination schedule in these countries.
The Vaccine Connection
In 1964, pharmaceutical giant Merck announced a new vaccine ingredient promising to extend immunity: Adjuvant 65-4, containing up to 65% peanut oil as well as aluminum stearate. An adjuvant (from the Latin “adjuvare,” to enhance) is a vaccine additive that stimulates the immune system, upping the body’s production of antibodies to a pathogen. Adjuvants reduce production costs as the vaccine maker needs less of the expensvie antigen; they also increase a vaccine’s efficacy. The (sic) can also be dangerous; the more effective a vaccine, the greater the risk of allergies and other adverse effects.
The inventor of Adjuvant 65-4, Maurice Hilleman and his colleagues at Merck knew that allergic sensitization to the peanut oil in the adjuvant was a distinct possibility, but considered toxicity and allergenicity inevitable outcomes of vaccination. It was simply difficult to balance potency and safety.
The public clearly did not know what was being injected into their children, called by immunologist Charles Janeway, “the immunologist’s dirty little secret.” The peanut allergy epidemic in children was precipitated by vaccines. Lawsuits ensued, especially related to the DPT vaccine. By 1985, over 200 lawsuits were pending against four vaccine manufacturers. This litigious environment caused many pharmaceutical companies to abandon the lucrative vaccine market, causing a vaccine shortage. A solution: combination or conjugate vaccines.
Vaccines were combined for convenience. With speed and efficiency the U.S. Pediatric vaccination schedule took off, helped by President Clinton’s Childhood Immunization Initiative in the mid-nineties. By 1998, childhood vaccination rates were at an all time high. So was the incidence of peanut allergy in children. Between 1997 and 2002, the peanut-allergic pediatric population in the U.S. grew by and average of 58,000 children a year, and doubled between 2002 and 2008. By 2008, more than one million children under 18 and another two million adults were allergic to peanuts in the United States alone.
According to Heather Fraser, “vaccination was the elephant in the middle of the room. Researchers glanced at it, knew it was there, but were reluctant to get too close.” The possibility that hundreds of thousands of children have been sensitized to peanuts by ingredients in one or more routine pediatic vaccinations is just too much to conceive. But it is too obvious to deny. The real clue is the sudden rise in peanut allergy following the escalation of the pediatric vaccine schedule.
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