I basically agree (I would phrase it slightly differently). Unfortunately, that's not what Popper and other adherents to skepticism say.
I know you said you'd like to set it aside, but since you brought it up: saying that you could be a brain in a vat ("The Matrix") or a computer simulation assumes the existence of a vat, a computer, a programmer, scientists, surgeons, electrodes, someone to put you in the vat, etc, etc. It's an attempt to use knowledge to destroy its own roots. Advanced knowledge presupposes more basic knowledge. You cannot rationally assert the certainty of advanced knowledge if the more basic knowledge is put in doubt.
In addition, for something to be possible, there must be at least some evidence for it. There is no evidence here, so such a claim is totally arbitrary (which also means it's not possible).
You're giving the skeptics too much credit, IMO. We can be more than just conditionally certain. Do you really have any doubt at all that jumping off a cliff will hurt you?
If you're interested, there are some great books on objective morality that might help sway you (one way or the other). Tara Smith's work is very good, as well as The Virtue of Selfishness.



), but I'm also open to the idea that there could be more than one right answer, and mine might not even be one of them...although I'd like to think it is.
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The probability of anything other than death upon impact (or severe mutilation?) is astronomically/negligibly small, but my hazy understanding is that the probability of you teleporting to China is technically not zero...and that's just working within known physical laws, ruling out actual skepticism.
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